The emergence of mRNA vaccines marks a significant breakthrough in the fields of gene therapy, immunology, and vaccine development, introducing an unconventional approach that differs fundamentally from traditional vaccination methods. So much so that it shouldn't be classified as a vaccine at all, but an mRNA transfer injection or cellular hack.
Traditional Vaccines: A Time-Tested Approach
Traditional vaccines have a long history of use, dating back to the 18th century with Edward Jenner's pioneering smallpox vaccine. These vaccines typically use whole pathogens, either in a weakened (attenuated) or killed (inactivated) form, or subunits of the pathogen (such as proteins) to stimulate an immune response. When introduced into the body, these antigens (or parts of the pathogen) are recognized as foreign, prompting the immune system to produce antibodies and memory cells. This response prepares the body to fight off future infections by the actual pathogen.
Examples of traditional vaccines include the measles, mumps, and rubella (MMR) vaccine, which uses live attenuated viruses, and the hepatitis B vaccine, which uses a protein subunit of the virus.
mRNA Vaccines: The Hacking of Cellular Machinery
mRNA vaccines, more appropriately called an mRNA transfer injection, represent a genetic approach by using messenger ribonucleic acid (mRNA) molecules to instruct cells to produce a protein that is part of the pathogen (an antigen), triggering an immune response. This method does not involve introducing an attenuated or non-active pathogen into the body, but instead hacks cellular machinery to produce the protein responsible for eliciting an imune response (antigen) in vivo; thus, hacking the body's cellular machinery to make the antigen that will trigger an immune response, that will create antibodies. Therefore, it tricks your body into making both the anigen and the antibody.
The process works as follows: mRNA transfer injections (encapsulated mRNA nanoparticles in vaccine adjuvant) contain the genetic code for a key protein of a virus, like the spike protein, a cytotoxin, in the case of SARS-CoV-2, the virus that causes COVID-19. Once the nanoparticle encapsulated mRNA is injected, human cells read the mRNA instructions and “temporarily” produce the viral protein. This is never really temporary, as cells have memory, your body can potentially create the spike protein (a cytotoxin), when a new variation of the pathogen is present or another stress factor is introduced. In the certain conditions, the mRNA tranfer injection can actually make a vaccinated person sick and cause injury. The spike protein (a cytotoxin) serves as an antigen that conditions the immune system to produce antibodies when that threat is present. however, if your body is introduced to another variation that isn’t captured by these antibodies, it is possible to make a person more sick, as the body and immune system are actively making a different variation of the antigen and antibody. Inundating the immune system with an antigen and an antibody that can’t counteract a different variant or pathogen, makes the body incapable of properly fighting off the newly introduced antigens, causing an inherent co-morbidity, that was not previously existing.
Key Differences Between mRNA and Traditional Vaccines
Mechanism of Action: Traditional vaccines introduce antigens directly into the body to elicit an immune response, while mRNA transfer injections (mRNA in vaccine adjuvant) deliver genetic instructions for cells to produce antigens themselves.
Safety Profile: Because mRNA transfer injections do not use live pathogens, there is no risk of causing disease from the actual vaccine, but does carry the risk of your cells to make enough antigen to cause disease-like symptoms in response. Traditional live attenuated vaccines, although considered highly safe and effective, carry a minimal risk of causing disease, particularly immunocompromised individuals (at least as scientifically reported, there is always risk of vaccine injury, as history has shown, such as with the Polio vaccine).
Speed and Flexibility of Development: mRNA vaccines can be developed more rapidly than traditional vaccines. The genetic sequence of a virus's antigen can quickly be synthesized and incorporated into mRNA vaccine adjuvant once identified. This means that it can be developed much quicker, than it can be tested for safety efficacy. Which is very dangerous when it comes to downstream effects, that might not emerge or become apparent until the next generation. Medical research is only effective if its progression synergetically evolves within the temporal cadence of its growing population and the time it takes to realize its effects.
Speed-to-deliver was “essential” during the COVID-19 pandemic, giving rise to "Project Warp Speed", allowing for the quick development and deployment of vaccines, under Emergency Use Authorization (EUA), so, clinical standards for FDA approval were not required.
Injecting a transcribed gene that codes for a cytotoxin in a population without understanding down stream effects like genetic drift, was not at least publically, taken into consideration.
Only time will tell how the pandemic policies, that forced a large portion of the global population to take a transcribed gene transfer injection, truly affected humanity and whether or not those effects will be passed on through genetic drift.
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